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Pranavanand Nyshadham
Pranavanand Nyshadham
Poseida Therapeutics
Verified email at poseida.com
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Year
Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library
S Dawadi, N Simmons, G Miklossy, KM Bohren, JC Faver, MN Ucisik, ...
Proceedings of the National Academy of Sciences 117 (29), 16782-16789, 2020
502020
Discovery and characterization of bromodomain 2–specific inhibitors of BRDT
Z Yu, AF Ku, JL Anglin, R Sharma, MN Ucisik, JC Faver, F Li, ...
Proceedings of the National Academy of Sciences 118 (9), e2021102118, 2021
492021
DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors
S Chamakuri, S Lu, MN Ucisik, KM Bohren, YC Chen, HC Du, JC Faver, ...
Proceedings of the National Academy of Sciences 118 (36), e2111172118, 2021
472021
Equivalency challenge: Evaluation of Lipodox® as the generic equivalent for Doxil® in a human ovarian cancer orthotropic mouse model
JA Smith, L Mathew, M Burney, P Nyshadham, RL Coleman
Gynecologic oncology 141 (2), 357-363, 2016
382016
Identifying oxacillinase-48 carbapenemase inhibitors using DNA-encoded chemical libraries
DM Taylor, J Anglin, S Park, MN Ucisik, JC Faver, N Simmons, Z Jin, ...
ACS infectious diseases 6 (5), 1214-1227, 2020
342020
Homogeneous and functional group tolerant ring-closing metathesis for DNA-encoded chemical libraries
OBC Monty, P Nyshadham, KM Bohren, M Palaniappan, MM Matzuk, ...
ACS combinatorial science 22 (2), 80-88, 2020
322020
Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment
L Mathew, M Burney, A Gaikwad, P Nyshadham, EK Nugent, A Gonzalez, ...
Integrative Cancer Therapies 16 (4), 572-584, 2017
272017
Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections
RK Modukuri, Z Yu, Z Tan, HM Ta, MN Ucisik, Z Jin, JL Anglin, KL Sharma, ...
Proceedings of the National Academy of Sciences 119 (22), e2122506119, 2022
222022
Mammalian target of rapamycin complex 2 signaling is required for liver regeneration in a cholestatic liver injury murine model
Y Zhou, M Xu, P Liu, B Liang, M Qian, H Wang, X Song, P Nyshadham, ...
The American journal of pathology 190 (7), 1414-1426, 2020
112020
Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library
S Chamakuri, MK Chung, ELG Samuel, KA Tran, YC Chen, P Nyshadham, ...
Bioorganic & Medicinal Chemistry 48, 116387, 2021
102021
Metabolism of a selective serotonin and norepinephrine reuptake inhibitor duloxetine in liver microsomes and mice
X Qin, JM Hakenjos, KR MacKenzie, M Barzi, H Chavan, P Nyshadham, ...
Drug Metabolism and Disposition 50 (2), 128-139, 2022
82022
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors
R Jimmidi, S Chamakuri, S Lu, MN Ucisik, PJ Chen, KM Bohren, ...
Communications Chemistry 6 (1), 164, 2023
22023
Identifying Metabolic Pathways of c‐MET Tyrosine Kinase Inhibitor Tepotinib in Human and Mouse Liver Microsomes
F Li, KR MacKenzie, P Nyshadham, KA Kerlec, MM Matzuk
The FASEB Journal 34 (S1), 1-1, 2020
22020
Effective Gene Therapy for Hemophilia a: Novel Re-Dosable Non-Viral Formulation That Provides Stable, and Durable FVIII Expression with Improved Tolerability
B Truong, K Hajj, J Schwerk, D Zhang, J Tamayo, G Guzelsoy, J Kubicki, ...
Blood 142, 1232, 2023
12023
Cyp1a2‐knockout increases the systemic exposure of a serotonin and norepinephrine reuptake inhibitor duloxetine in mice
X Qin, C Xie, JM Hakenjos, KM Mackenzie, M Barzi, P Nyshadham, ...
The FASEB Journal 36, 2022
12022
Corrigendum to ‘Equivalency challenge: evaluation of Lipodox® as the generic equivalent for Doxil® in a human ovarian cancer orthotropic mouse model’[Gynecol. Oncol. 141 (2016 …
JA Smith, L Mathew, M Burney, P Nyshadham, RL Coleman
Gynecologic oncology 144 (2), 448, 2017
12017
Equivalency challenge: evaluation of Lipodox as the generic equivalent for Doxil in a human ovarian cancer orthotropic mouse model (vol 141, pg 357, 2016)
JA Smith, L Mathew, M Burney, P Nyshadham, RL Coleman
GYNECOLOGIC ONCOLOGY 144 (2), 448-448, 2017
12017
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