A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 63 | 2022 |
Diverse catalytic reactions for the stereoselective synthesis of cyclic dinucleotide MK-1454 T Benkovics, F Peng, EM Phillips, C An, RS Bade, CK Chung, ZEX Dance, ... Journal of the American Chemical Society 144 (13), 5855-5863, 2022 | 33 | 2022 |
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 PS Fier, Y Xu, M Poirier, G Brito, M Zheng, R Bade, E Sirota, K Stone, ... Organic process research & development 25 (12), 2806-2815, 2021 | 19 | 2021 |
Canada, KA; Bulger, PG; Sherry, BD; Truppo, M. D.; Ruck, RT; Campeau, L.-C.; Bennett, DJ; Humphrey, GR; Campos, KR; Maddess, ML A Kinase-cGAS Cascade to Synthesize a … JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 15 | 2022 |
KA Canada, PG Bulger, BD Sherry, MD Truppo, RT Ruck, L.-C. Campeau, DJ Bennett, GR Humphrey, KR Campos and ML Maddess, A Kinase-cGAS Cascade to Synthesize a Therapeutic STING … JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603, 439-444, 2022 | 10 | 2022 |
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19 R Bade, JR Bothe, E Sirota, APJ Brunskill, JA Newman, Y Zhang, M Tan, ... Organic Process Research & Development 27 (11), 2100-2110, 2023 | | 2023 |
Enabling Technologies: Mechanistic and statistical modeling NC Dalvie, R Bade 2022 AIChE Annual Meeting, 2022 | | 2022 |
Accelerated Process Design and Optimization for a Small Molecule COVID-19 Therapeutic M Zheng, R Bade, K Stone, P Fier, G Brito, S Castro 2021 AIChE Annual Meeting, 2021 | | 2021 |
Crystallization Development for Molnupiravir, an Investigational Antiviral for the Treatment of COVID-19 R Bade, M Zheng, M Poirer, G Brito, E Sirota, J Bothe, D Chang, ... 2021 AIChE Annual Meeting, 2021 | | 2021 |
Recrystallization Development for Small Molecule API (Active Pharmaceutical Ingredient) Islatravir R Bade, R Varsolona, D Stueber, K Sirk, J Heltzel, A Koynov, ... 2020 Virtual AIChE Annual Meeting, 2020 | | 2020 |
Co-Immobilization of Enzyme Cascades Enables One-Pot Industrial Immobilized Biocatalysis J Forstater, R Bade, SA Robaire, C An, JN Kolev, ST Grosser 2019 AIChE Annual Meeting, 2019 | | 2019 |
Development of Multi-Enzyme Immobilized Biocatalytic Processes for Synthesis of Small Molecule APIs R Bade, J Forstater, ST Grosser, JP Corry 2019 AIChE Annual Meeting, 2019 | | 2019 |