A syndromic neurodevelopmental disorder caused by mutations in SMARCD1, a core SWI/SNF subunit needed for context-dependent neuronal gene regulation in flies KCJ Nixon, J Rousseau, MH Stone, M Sarikahya, S Ehresmann, S Mizuno, ... The American Journal of Human Genetics 104 (4), 596-610, 2019 | 43 | 2019 |
Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy SMK Farhan, KCJ Nixon, M Everest, TN Edwards, S Long, D Segal, ... Human molecular genetics 26 (21), 4278-4289, 2017 | 41 | 2017 |
Mushroom body specific transcriptome analysis reveals dynamic regulation of learning and memory genes after acquisition of long-term courtship memory in Drosophila SG Jones, KCJ Nixon, MC Chubak, JM Kramer G3: Genes, Genomes, Genetics 8 (11), 3433-3446, 2018 | 38 | 2018 |
Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body MC Chubak, KCJ Nixon, MH Stone, N Raun, SL Rice, M Sarikahya, ... Disease Models & Mechanisms 12 (3), dmm037325, 2019 | 20 | 2019 |
Targeting the ubiquitin–proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small-cell lung cancer S Majeed, MK Aparnathi, KCJ Nixon, V Venkatasubramanian, F Rahman, ... Clinical Cancer Research 28 (9), 1966-1978, 2022 | 16 | 2022 |
Proteinase-activated receptor 4 activation triggers cell membrane blebbing through RhoA and β-arrestin CMG Vanderboor, PE Thibeault, KCJ Nixon, R Gros, J Kramer, ... Molecular Pharmacology 97 (6), 365-376, 2020 | 10 | 2020 |
Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies Y Yang, J Ahn, NJ Edwards, J Benicky, AM Rozeboom, B Davidson, ... Cancers 14 (22), 5553, 2022 | 9 | 2022 |
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers PS Patel, A Algouneh, R Krishnan, JJ Reynolds, KCJ Nixon, J Hao, J Lee, ... Nucleic Acids Research 51 (9), 4341-4362, 2023 | 7 | 2023 |
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells R Krishnan, M Lapierre, B Gautreau, KCJ Nixon, S El Ghamrasni, ... Nucleic Acids Research 51 (19), 10484-10505, 2023 | 4 | 2023 |
Identification of SMARCD1 as a syndromic intellectual disability gene that is required for memory and context-dependent regulation of neuronal genes in Drosophila KCJ Nixon, J Rousseau, MH Stone, M Sarikahya, S Ehresmann, S Mizuno, ... BioRxiv, 422188, 2018 | 2 | 2018 |
The first-in-class UBA1 inhibitor, TAK-243, in combination with radiotherapy for YAP1 and BEND3 biomarker-defined small cell lung cancer S Majeed, M Aparnathi, L Song, J Weiss, V Venkatasubramanian, ... International Journal of Radiation Oncology, Biology, Physics 111 (3), e467, 2021 | 1 | 2021 |
CRISPR Screen of Druggable Targets in Small Cell Lung Cancer Identified ATM Inhibitor (AZD1390) as a Radiosensitizer X Ran, BX Wu, M Shi, L Song, K Nixon, V Philip, HH He, MS Tsao, BH Lok International Journal of Radiation Oncology* Biology* Physics 118 (5), 1308-1314, 2024 | | 2024 |
Insulin receptor loss impairs mammary tumorigenesis in mice L Podmore, Y Poloz, C Iorio, S Mouaaz, K Nixon, P Smirnov, B McDonnell, ... Cell Reports 42 (11), 2023 | | 2023 |
Mushroom body-specific gene regulation by the SWI/SNF chromatin remodeling complex KCJ Nixon The University of Western Ontario (Canada), 2020 | | 2020 |
Identification of a Novel Synaptic Protein, TMTC3, Involved in Periventricular Nodular Heterotopia with Intellectual Disability and Epilepsy KCJ Nixon, M Everest, TN Edwards, S Long, D Segal, MJ Knip, HH Arts, ... | | 2017 |