Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer MG Costales, H Aikawa, Y Li, JL Childs-Disney, D Abegg, DG Hoch, ... Proceedings of the National Academy of Sciences 117 (5), 2406-2411, 2020 | 151 | 2020 |
Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor D Abegg, G Gasparini, DG Hoch, A Shuster, E Bartolami, S Matile, ... Journal of the American Chemical Society 139 (1), 231-238, 2017 | 124 | 2017 |
Cysteine-reactive probes and their use in chemical proteomics DG Hoch, D Abegg, A Adibekian Chemical Communications 54 (36), 4501-4512, 2018 | 72 | 2018 |
A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin MG Costales, DG Hoch, D Abegg, JL Childs-Disney, SP Velagapudi, ... Journal of the American Chemical Society 141 (7), 2960-2974, 2019 | 66 | 2019 |
Chemoproteomics‐Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT C Wang, D Abegg, DG Hoch, A Adibekian Angewandte Chemie International Edition 55 (8), 2911-2915, 2016 | 57 | 2016 |
Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids DC Davis, DG Hoch, L Wu, D Abegg, BS Martin, ZY Zhang, A Adibekian, ... Journal of the American Chemical Society 140 (50), 17465-17473, 2018 | 45 | 2018 |
Divergent synthesis and identification of the cellular targets of deoxyelephantopins R Lagoutte, C Serba, D Abegg, DG Hoch, A Adibekian, N Winssinger Nature communications 7 (1), 1-11, 2016 | 44 | 2016 |
Total synthesis and target identification of the curcusone diterpenes C Cui, BG Dwyer, C Liu, D Abegg, ZJ Cai, DG Hoch, X Yin, N Qiu, JQ Liu, ... Journal of the American Chemical Society 143 (11), 4379-4386, 2021 | 28 | 2021 |
Combined omics approach identifies gambogic acid and related xanthones as covalent inhibitors of the serine palmitoyltransferase complex DG Hoch, D Abegg, JT Hannich, D Pechalrieu, A Shuster, BG Dwyer, ... Cell chemical biology 27 (5), 586-597. e12, 2020 | 23 | 2020 |
Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism BG Dwyer, C Wang, D Abegg, B Racioppo, N Qiu, Z Zhao, D Pechalrieu, ... Angewandte Chemie International Edition 60 (6), 3071-3079, 2021 | 15 | 2021 |
Chemoproteomik‐vermittelte Entdeckung eines potenten und selektiven Inhibitors des DNA‐Reparaturproteins MGMT C Wang, D Abegg, DG Hoch, A Adibekian Angewandte Chemie 128 (8), 2964-2968, 2016 | 5 | 2016 |
Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery DG Hoch, D Abegg, C Wang, A Shuster, A Adibekian Chimia 70 (11), 764-764, 2016 | 2 | 2016 |
Total synthesis and chemoproteomics connect curcusone diterpenes with oncogenic protein BRAT1 C Cui, BG Dwyer, C Liu, D Abegg, Z Cai, D Hoch, X Yin, N Qiu, J Liu, ... | 1 | 2020 |
Sesquiterpenoid analogs M Dai, DC Davis, A Adibekian, DG Hoch, ZY Zhang US Patent 11,814,396, 2023 | | 2023 |
Sesquiterpenoid analogs M Dai, DC Davis, A Adibekian, DG Hoch, ZY Zhang US Patent 11,518,770, 2022 | | 2022 |
Chapter V. A Kinetically Attenuated Ethynylbenziodoxole Probe for Chemoproteomic Profiling Covalent Reversible and Slow-Binding Drugs C Reversible, BG Dwyer, R Tessier, D Abegg, Z Zhao, DG Hoch, ... Chemoproteomic Tools for Profiling Bioactive Small Molecules: From De Novo …, 2022 | | 2022 |
Chapter III. Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism BG Dwyer, C Wang, D Abegg, B Racioppo, N Qiu, Z Zhao, D Pechalrieu, ... Chemoproteomic Tools for Profiling Bioactive Small Molecules: From De Novo …, 2022 | | 2022 |
RIBOTACs–Targeted Degradation of RNA D Trauner, KP Ruehmann Synfacts 16 (04), 0463, 2020 | | 2020 |
RIBOTACs–Targeted Degradation of RNA MG COSTALES, H AIKAWA, Y LI, JL CHILDS-DISNEY, D ABEGG, ... Proc. Natl. Acad. Sci. USA 117, 2406-2411, 2020 | | 2020 |
Total Syntheses of Abies Sesquiterpenoids EM Carreira, M Hönig Synfacts 15 (02), 0120, 2019 | | 2019 |