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Shunhai Wang
Shunhai Wang
Regeneron Pharmaceutical, Inc; UMASS, Amherst
Verified email at regeneron.com
Title
Cited by
Cited by
Year
Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics
IA Kaltashov, CE Bobst, RR Abzalimov, G Wang, B Baykal, S Wang
Biotechnology advances 30 (1), 210-222, 2012
1632012
Ultrasensitive characterization of charge heterogeneity of therapeutic monoclonal antibodies using strong cation exchange chromatography coupled to native mass spectrometry
Y Yan, AP Liu, S Wang, TJ Daly, N Li
Analytical chemistry 90 (21), 13013-13020, 2018
1022018
Coupling mixed-mode size exclusion chromatography with native mass spectrometry for sensitive detection and quantitation of homodimer impurities in bispecific IgG
Y Yan, T Xing, S Wang, TJ Daly, N Li
Analytical chemistry 91 (17), 11417-11424, 2019
472019
Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry
S Wang, AP Liu, Y Yan, TJ Daly, N Li
Journal of pharmaceutical and biomedical analysis 154, 468-475, 2018
412018
Characterization of adeno-associated virus capsid proteins using hydrophilic interaction chromatography coupled with mass spectrometry
AP Liu, SK Patel, T Xing, Y Yan, S Wang, N Li
Journal of pharmaceutical and biomedical analysis 189, 113481, 2020
352020
Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products
Y Yan, T Xing, S Wang, TJ Daly, N Li
Journal of Pharmaceutical and Biomedical Analysis 186, 113313, 2020
352020
Versatile, sensitive, and robust native LC–MS platform for intact mass analysis of protein drugs
Y Yan, T Xing, S Wang, N Li
Journal of the American Society for Mass Spectrometry 31 (10), 2171-2179, 2020
322020
Pitfalls in Protein Quantitation Using Acid-Catalyzed O18 Labeling: Hydrolysis-Driven Deamidation
S Wang, CE Bobst, IA Kaltashov
Analytical chemistry 83 (18), 7227-7232, 2011
272011
Simple Approach for Improved LC-MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas
S Wang, T Xing, AP Liu, Z He, Y Yan, TJ Daly, N Li
Analytical chemistry, 2019
252019
A New Strategy of Using O18-Labeled Iodoacetic Acid for Mass Spectrometry-Based Protein Quantitation
S Wang, IA Kaltashov
Journal of the American Society for Mass Spectrometry 23 (7), 1293-1297, 2012
232012
An 18O-Labeling Assisted LC/MS Method for Assignment of Aspartyl/Isoaspartyl Products from Asn Deamidation and Asp Isomerization in Proteins
S Wang, IA Kaltashov
Analytical chemistry 85 (13), 6446-6452, 2013
212013
Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery
CE Bobst, S Wang, WC Shen, IA Kaltashov
Proceedings of the National Academy of Sciences 109 (34), 13544-13548, 2012
202012
Identification of Reduction-Susceptible Disulfide Bonds in Transferrin by Differential Alkylation Using O16/O18 Labeled Iodoacetic Acid
S Wang, IA Kaltashov
Journal of The American Society for Mass Spectrometry 26 (5), 800-807, 2015
172015
Coupling anion exchange chromatography with native mass spectrometry for charge heterogeneity characterization of monoclonal antibodies
AP Liu, Y Yan, S Wang, N Li
Analytical chemistry 94 (16), 6355-6362, 2022
162022
Emerging mass spectrometry-based approaches to probe protein–receptor interactions: Focus on overcoming physiological barriers
IA Kaltashov, CE Bobst, SN Nguyen, S Wang
Advanced drug delivery reviews 65 (8), 1020-1030, 2013
152013
Evaluation of nonferrous metals as potential in vivo tracers of transferrin-based therapeutics
H Zhao, S Wang, SN Nguyen, SG Elci, IA Kaltashov
Journal of The American Society for Mass Spectrometry 27 (2), 211-219, 2015
142015
Mass Spectrometry in Biopharmaceutical Analysis
IA Kaltashov, S Wang, G Wang
Walter de Gruyter GmbH & Co KG, 2021
72021
Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in …
Y Yan, T Xing, AP Liu, Z Zhang, S Wang, N Li
Journal of the American Society for Mass Spectrometry 32 (12), 2885-2894, 2021
52021
An 18O-Labeling Assisted LC–MS Method for Accurate Quantitation of Unprocessed C-Terminal Lysine in Therapeutic Monoclonal Antibodies
S Wang, AP Liu, N Li
Journal of the American Society for Mass Spectrometry 31 (7), 1587-1592, 2020
42020
A new liquid chromatography–mass spectrometry-based method to quantitate exogenous recombinant transferrin in cerebrospinal fluid: a potential approach for pharmacokinetic …
S Wang, CE Bobst, IA Kaltashov
European Journal of Mass Spectrometry 21 (3), 369-376, 2015
42015
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