Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics IA Kaltashov, CE Bobst, RR Abzalimov, G Wang, B Baykal, S Wang Biotechnology advances 30 (1), 210-222, 2012 | 163 | 2012 |
Ultrasensitive characterization of charge heterogeneity of therapeutic monoclonal antibodies using strong cation exchange chromatography coupled to native mass spectrometry Y Yan, AP Liu, S Wang, TJ Daly, N Li Analytical chemistry 90 (21), 13013-13020, 2018 | 102 | 2018 |
Coupling mixed-mode size exclusion chromatography with native mass spectrometry for sensitive detection and quantitation of homodimer impurities in bispecific IgG Y Yan, T Xing, S Wang, TJ Daly, N Li Analytical chemistry 91 (17), 11417-11424, 2019 | 47 | 2019 |
Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry S Wang, AP Liu, Y Yan, TJ Daly, N Li Journal of pharmaceutical and biomedical analysis 154, 468-475, 2018 | 41 | 2018 |
Characterization of adeno-associated virus capsid proteins using hydrophilic interaction chromatography coupled with mass spectrometry AP Liu, SK Patel, T Xing, Y Yan, S Wang, N Li Journal of pharmaceutical and biomedical analysis 189, 113481, 2020 | 35 | 2020 |
Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products Y Yan, T Xing, S Wang, TJ Daly, N Li Journal of Pharmaceutical and Biomedical Analysis 186, 113313, 2020 | 35 | 2020 |
Versatile, sensitive, and robust native LC–MS platform for intact mass analysis of protein drugs Y Yan, T Xing, S Wang, N Li Journal of the American Society for Mass Spectrometry 31 (10), 2171-2179, 2020 | 32 | 2020 |
Pitfalls in Protein Quantitation Using Acid-Catalyzed O18 Labeling: Hydrolysis-Driven Deamidation S Wang, CE Bobst, IA Kaltashov Analytical chemistry 83 (18), 7227-7232, 2011 | 27 | 2011 |
Simple Approach for Improved LC-MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas S Wang, T Xing, AP Liu, Z He, Y Yan, TJ Daly, N Li Analytical chemistry, 2019 | 25 | 2019 |
A New Strategy of Using O18-Labeled Iodoacetic Acid for Mass Spectrometry-Based Protein Quantitation S Wang, IA Kaltashov Journal of the American Society for Mass Spectrometry 23 (7), 1293-1297, 2012 | 23 | 2012 |
An 18O-Labeling Assisted LC/MS Method for Assignment of Aspartyl/Isoaspartyl Products from Asn Deamidation and Asp Isomerization in Proteins S Wang, IA Kaltashov Analytical chemistry 85 (13), 6446-6452, 2013 | 21 | 2013 |
Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery CE Bobst, S Wang, WC Shen, IA Kaltashov Proceedings of the National Academy of Sciences 109 (34), 13544-13548, 2012 | 20 | 2012 |
Identification of Reduction-Susceptible Disulfide Bonds in Transferrin by Differential Alkylation Using O16/O18 Labeled Iodoacetic Acid S Wang, IA Kaltashov Journal of The American Society for Mass Spectrometry 26 (5), 800-807, 2015 | 17 | 2015 |
Coupling anion exchange chromatography with native mass spectrometry for charge heterogeneity characterization of monoclonal antibodies AP Liu, Y Yan, S Wang, N Li Analytical chemistry 94 (16), 6355-6362, 2022 | 16 | 2022 |
Emerging mass spectrometry-based approaches to probe protein–receptor interactions: Focus on overcoming physiological barriers IA Kaltashov, CE Bobst, SN Nguyen, S Wang Advanced drug delivery reviews 65 (8), 1020-1030, 2013 | 15 | 2013 |
Evaluation of nonferrous metals as potential in vivo tracers of transferrin-based therapeutics H Zhao, S Wang, SN Nguyen, SG Elci, IA Kaltashov Journal of The American Society for Mass Spectrometry 27 (2), 211-219, 2015 | 14 | 2015 |
Mass Spectrometry in Biopharmaceutical Analysis IA Kaltashov, S Wang, G Wang Walter de Gruyter GmbH & Co KG, 2021 | 7 | 2021 |
Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in … Y Yan, T Xing, AP Liu, Z Zhang, S Wang, N Li Journal of the American Society for Mass Spectrometry 32 (12), 2885-2894, 2021 | 5 | 2021 |
An 18O-Labeling Assisted LC–MS Method for Accurate Quantitation of Unprocessed C-Terminal Lysine in Therapeutic Monoclonal Antibodies S Wang, AP Liu, N Li Journal of the American Society for Mass Spectrometry 31 (7), 1587-1592, 2020 | 4 | 2020 |
A new liquid chromatography–mass spectrometry-based method to quantitate exogenous recombinant transferrin in cerebrospinal fluid: a potential approach for pharmacokinetic … S Wang, CE Bobst, IA Kaltashov European Journal of Mass Spectrometry 21 (3), 369-376, 2015 | 4 | 2015 |