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Zhen Wang
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Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
C Ambrogio, G Gomez-Lopez, M Falcone, A Vidal, E Nadal, N Crosetto, ...
Nature medicine 22 (3), 270-277, 2016
1862016
Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma
KY Aguilera, H Huang, W Du, MM Hagopian, Z Wang, S Hinz, TH Hwang, ...
Molecular cancer therapeutics 16 (11), 2473-2485, 2017
962017
Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives
Z Wang, Z Li, H Ji
Medicinal research reviews 41 (4), 2109-2129, 2021
792021
Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer
Y Qiao, JE Choi, JC Tien, SA Simko, T Rajendiran, JN Vo, AD Delekta, ...
Nature cancer 2 (9), 978-993, 2021
622021
Structure-based design of tetrahydroisoquinoline-7-carboxamides as selective discoidin domain receptor 1 (DDR1) inhibitors
Z Wang, H Bian, SG Bartual, W Du, J Luo, H Zhao, S Zhang, C Mo, Y Zhou, ...
Journal of medicinal chemistry 59 (12), 5911-5916, 2016
612016
Structure-based optimization of small-molecule inhibitors for the β-catenin/b-cell lymphoma 9 protein–protein interaction
M Zhang, Z Wang, Y Zhang, W Guo, H Ji
Journal of medicinal chemistry 61 (7), 2989-3007, 2018
372018
Tetrahydroisoquinoline-7-carboxamide derivatives as new selective discoidin domain receptor 1 (DDR1) inhibitors
Z Wang, Y Zhang, SG Bartual, J Luo, T Xu, W Du, Q Xun, Z Tu, ...
ACS medicinal chemistry letters 8 (3), 327-332, 2017
372017
Small-molecule CSF1R inhibitors as anticancer agents
Q Xun, Z Wang, X Hu, K Ding, X Lu
Current medicinal chemistry 27 (23), 3944-3966, 2020
332020
Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl …
Z Wang, Y Zhang, DM Pinkas, AE Fox, J Luo, H Huang, S Cui, Q Xiang, ...
Journal of medicinal chemistry 61 (17), 7977-7990, 2018
322018
Small-molecule BET inhibitors in clinical and preclinical development and their therapeutic potential
L Yu, Z Wang, Z Zhang, X Ren, X Lu, K Ding
Current topics in medicinal chemistry 15 (8), 776-794, 2015
302015
Optimization of peptidomimetics as selective inhibitors for the β-catenin/T-cell factor protein–protein interaction
Z Wang, M Zhang, J Wang, H Ji
Journal of medicinal chemistry 62 (7), 3617-3635, 2019
232019
Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13
J Yang, Y Chang, JCY Tien, Z Wang, Y Zhou, P Zhang, W Huang, J Vo, ...
Journal of Medicinal Chemistry 65 (16), 11066-11083, 2022
222022
Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms
NK Tafreshi, DN Pandya, CJ Tichacek, MM Budzevich, Z Wang, JN Reff, ...
European journal of nuclear medicine and molecular imaging 48, 3408-3421, 2021
222021
Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R …
Q Xun, Z Zhang, J Luo, L Tong, M Huang, Z Wang, J Zou, Y Liu, Y Xu, ...
Journal of Medicinal Chemistry 61 (6), 2353-2371, 2018
202018
Targeting the non-catalytic functions: a new paradigm for kinase drug discovery?
Z Wang, W Huang, K Zhou, X Ren, K Ding
Journal of Medicinal Chemistry 65 (3), 1735-1748, 2022
182022
Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl) phenoxy) acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction
Z Wang, M Zhang, W Luo, Y Zhang, H Ji
Journal of Medicinal Chemistry 64 (9), 5886-5904, 2021
132021
A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB
Y Lin, Q Shi, G Yang, F Shi, Y Zhou, T Wang, P Xu, P Li, Z Liu, H Sun, ...
Proceedings of the National Academy of Sciences 120 (7), e2213670120, 2023
112023
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction
Z Wang, M Zhang, V Quereda, SM Frydman, Q Ming, VC Luca, ...
Journal of medicinal chemistry 64 (16), 12109-12131, 2021
92021
Discovery of AXL degraders with improved potencies in triple-negative breast cancer (TNBC) cells
R He, Z Song, Y Bai, S He, J Huang, Y Wang, F Zhou, W Huang, J Guo, ...
Journal of Medicinal Chemistry 66 (3), 1873-1891, 2023
82023
GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models
J Zou, Z Zhang, F Xu, S Cui, C Qi, J Luo, Z Wang, X Lu, Z Tu, X Ren, ...
Journal of Drug Targeting 27 (4), 442-450, 2019
82019
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