| NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction C Zhang, HJ Wang, QC Bao, L Wang, TK Guo, WL Chen, LL Xu, HS Zhou, ... Oncotarget 7 (45), 73593, 2016 | 121 | 2016 |
| Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer L Wang, L Zhang, L Li, J Jiang, Z Zheng, J Shang, C Wang, W Chen, ... Science Advances 5 (9), eaax2277, 2019 | 61 | 2019 |
| Discovery and modification of in vivo active Nrf2 activators with 1, 2, 4-oxadiazole core: hits identification and structure–activity relationship study LL Xu, JF Zhu, XL Xu, J Zhu, L Li, MY Xi, ZY Jiang, MY Zhang, F Liu, M Lu, ... Journal of medicinal chemistry 58 (14), 5419-5436, 2015 | 53 | 2015 |
| Optimization and biological evaluation of celastrol derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties F Jiang, HJ Wang, QC Bao, L Wang, YH Jin, Q Zhang, D Jiang, QD You, ... Bioorganic & medicinal chemistry 24 (21), 5431-5439, 2016 | 48 | 2016 |
| Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90 F Jiang, HJ Wang, YH Jin, Q Zhang, ZH Wang, JM Jia, F Liu, L Wang, ... Journal of medicinal chemistry 59 (23), 10498-10519, 2016 | 38 | 2016 |
| Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo X Xu, Y Wu, M Hu, X Li, Q Bao, J Bian, Q You, X Zhang Scientific reports 6 (1), 35771, 2016 | 27 | 2016 |
| Affinity-based fluorescence polarization assay for high-throughput screening of prolyl hydroxylase 2 inhibitors Y Lei, T Hu, X Wu, Y Wu, Q Bao, L Zhang, H Xia, H Sun, Q You, X Zhang ACS medicinal chemistry letters 6 (12), 1236-1240, 2015 | 25 | 2015 |
| Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction L Wang, QC Bao, XL Xu, F Jiang, K Gu, ZY Jiang, XJ Zhang, XK Guo, ... RSC advances 5 (116), 96138-96145, 2015 | 21 | 2015 |
| Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline T Feng, D Li, H Wang, J Zhuang, F Liu, Q Bao, Y Lei, W Chen, X Zhang, ... European journal of medicinal chemistry 105, 145-155, 2015 | 20 | 2015 |
| Escape, or vanish: control the fate of p53 through MDM2-mediated ubiquitination J Wei, Y Yang, M Lu, L Xu, F Liu, Z Yuan, Q Bao, Z Jiang, X Xu, X Guo, ... Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2016 | 13 | 2016 |
| CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells XL Xu, Q Bao, JM Jia, F Liu, XK Guo, M Zhang, J Wei, M Lu, L Xu, ... Scientific reports 6 (1), 19004, 2016 | 10 | 2016 |
| Hydrogen peroxide inducible JAK3 covalent inhibitor: prodrug for the treatment of RA with enhanced safety profile Q Bao, L Zhang, N Wang, B Gabet, W Yang, X Gao, Q You, Z Jiang ACS Medicinal Chemistry Letters 11 (11), 2182-2189, 2020 | 8 | 2020 |
| Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach T Feng, W Chen, D Li, H Lin, F Liu, Q Bao, Y Lei, X Zhang, X Xu, X Guo, ... RSC Advances 5 (101), 82936-82946, 2015 | 7 | 2015 |
| Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism QC Bao, L Wang, L Wang, XL Xu, F Jiang, F Liu, XJ Zhang, XK Guo, ... RSC advances 6 (48), 42537-42544, 2016 | 5 | 2016 |
| Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain X Chen, D Cao, C Liu, F Meng, Z Zhang, R Xu, Y Tong, Y Xin, W Zhang, ... Journal of medicinal chemistry 66 (13), 8725-8744, 2023 | 3 | 2023 |
| Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis X Chen, T Wu, Z Du, W Kang, R Xu, F Meng, C Liu, Y Chen, Q Bao, ... European Journal of Medicinal Chemistry 265, 116080, 2024 | 1 | 2024 |
| Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation C Zhang, HJ Wang, QC Bao, JL Bian, YR Yang, QD You, XL Xu RSC advances 6 (61), 56738-56746, 2016 | 1 | 2016 |
| A JAK tyrosine kinase and pseudokinase Co-inhibition strategy combines enhanced potency and on-demand activation X Chen, L Zhang, Q Bao, F Meng, C Liu, R Xu, X Ji, Q You, Z Jiang European journal of medicinal chemistry 250, 115198, 2023 | | 2023 |
