Thomas Gaj
Thomas Gaj
Assistant Professor of Bioengineering, University of Illinois
Verified email at - Homepage
Cited by
Cited by
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
T Gaj, CA Gersbach, CF Barbas III
Trends in Biotechnology 31 (7), 397-405, 2013
A designer AAV variant permits efficient retrograde access to projection neurons
DGR Tervo, BY Hwang, S Viswanathan, T Gaj, M Lavzin, KD Ritola, ...
Neuron 92 (2), 372-382, 2016
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
T Gaj, J Guo, Y Kato, SJ Sirk, CF Barbas III
Nature Methods 9 (8), 805-807, 2012
Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases
J Guo, T Gaj, CF Barbas III
Journal of Molecular Biology 400 (1), 96-107, 2010
Genome-editing technologies: principles and applications
T Gaj, SJ Sirk, S Shui, J Liu
Cold Spring Harbor Perspectives in Biology 8 (12), a023754, 2016
Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering
J Liu, T Gaj, JT Patterson, SJ Sirk, CF Barbas III
PLOS ONE 9 (1), e85755, 2014
Chimeric TALE recombinases with programmable DNA sequence specificity
AC Mercer, T Gaj, RP Fuller, CF Barbas III
Nucleic Acids Research 40 (21), 11163-11172, 2012
Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
J Liu, T Gaj, Y Yang, N Wang, S Shui, S Kim, CN Kanchiswamy, JS Kim, ...
Nature Protocols 10 (11), 1842-1859, 2015
Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies
CA Gersbach, T Gaj, CF Barbas III
Accounts of Chemical Research 47 (8), 2309-2318, 2014
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
T Gaj, DS Ojala, FK Ekman, LC Byrne, P Limsirichai, DV Schaffer
Science Advances 3 (12), eaar3952, 2017
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
CA Gersbach, T Gaj, RM Gordley, AC Mercer, CF Barbas III
Nucleic Acids Research 39 (17), 7868-7878, 2011
CRISPR-mediated activation of latent HIV-1 expression
P Limsirichai, T Gaj, DV Schaffer
Molecular Therapy 24 (3), 499-507, 2016
Genome engineering using adeno-associated virus: basic and clinical research applications
T Gaj, BE Epstein, DV Schaffer
Molecular Therapy 24 (3), 458-464, 2016
A hypothalamic switch for REM and non-REM sleep
KS Chen, M Xu, Z Zhang, WC Chang, T Gaj, DV Schaffer, Y Dan
Neuron 97 (5), 1168-1176, 2018
Treatment of a mouse model of ALS by in vivo base editing
CKW Lim, M Gapinske, AK Brooks, WS Woods, JE Powell, CMA Zeballos, ...
Molecular Therapy 28 (4), 1177-1189, 2020
Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A
SC Meyer, CD Shomin, T Gaj, I Ghosh
Journal of the American Chemical Society 129 (45), 13812-13813, 2007
Structure-guided reprogramming of serine recombinase DNA sequence specificity
T Gaj, AC Mercer, CA Gersbach, RM Gordley, CF Barbas III
Proceedings of the National Academy of Sciences 108 (2), 498-503, 2011
CRISPR-Cas9-mediated genome editing increases lifespan and improves motor deficits in a Huntington’s disease mouse model
FK Ekman, DS Ojala, MM Adil, PA Lopez, DV Schaffer, T Gaj
Molecular Therapy – Nucleic Acids 17, 829-839, 2019
Expanding the scope of site‐specific recombinases for genetic and metabolic engineering
T Gaj, SJ Sirk, CF Barbas III
Biotechnology and Bioengineering 111 (1), 1-15, 2014
Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering
J Liu, T Gaj, MC Wallen, CF Barbas III
Molecular Therapy – Nucleic Acids 4 (3), e232, 2015
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