Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer L Xiao, A Parolia, Y Qiao, P Bawa, S Eyunni, R Mannan, SE Carson, ... Nature 601 (7893), 434-439, 2022 | 129 | 2022 |
Identification of new small-molecule inducers of estrogen-related receptor α (ERRα) degradation L Peng, Z Zhang, C Lei, S Li, Z Zhang, X Ren, Y Chang, Y Zhang, Y Xu, ... ACS medicinal chemistry letters 10 (5), 767-772, 2019 | 53 | 2019 |
Cell‐and Tissue‐Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin D Zhu, H Guo, Y Chang, Y Ni, L Li, ZM Zhang, P Hao, Y Xu, K Ding, Z Li Angewandte Chemie International Edition 57 (30), 9284-9289, 2018 | 35 | 2018 |
Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib H Cheng, Y Chang, L Zhang, J Luo, Z Tu, X Lu, Q Zhang, J Lu, X Ren, ... Journal of Medicinal Chemistry 57 (6), 2692-2703, 2014 | 35 | 2014 |
Chemistry, Bioactivity, and the Structure-Activity Relationship of Cephalotaxine-Type Alkaloids From Cephalotaxus sp. Y Chang, FC Meng, R Wang, CM Wang, XY Lu, QW Zhang Studies in Natural Products Chemistry 53, 339-373, 2017 | 27 | 2017 |
Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening C Guo, Y Chang, X Wang, C Zhang, P Hao, K Ding, Z Li Chemical communications 55 (6), 834-837, 2019 | 26 | 2019 |
Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK … Y Chang, X Lu, MA Shibu, YB Dai, J Luo, Y Zhang, Y Li, P Zhao, Z Zhang, ... Journal of Medicinal Chemistry 60 (13), 5927-5932, 2017 | 26 | 2017 |
Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13 J Yang, Y Chang, JCY Tien, Z Wang, Y Zhou, P Zhang, W Huang, J Vo, ... Journal of Medicinal Chemistry 65 (16), 11066-11083, 2022 | 22 | 2022 |
Pyrido [2, 3-d] pyrimidin-7 (8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors M Huang, Y Huang, J Guo, L Yu, Y Chang, X Wang, J Luo, Y Huang, Z Tu, ... European Journal of Medicinal Chemistry 211, 113023, 2021 | 18 | 2021 |
Tyrosine kinase 2 (TYK2) allosteric inhibitors to treat autoimmune diseases Y Chang, S Xu, K Ding Journal of Medicinal Chemistry 62 (20), 8951-8952, 2019 | 18 | 2019 |
A new cycloartane-type triterpenoid from the roots of Dianella ensifolia (L.) DC BQ Tang, CW Li, JB Sun, Y Chang, JYW Chan, SMY Lee, B Zeng Natural product research 31 (8), 966-971, 2017 | 15 | 2017 |
Crenolanib‐Derived Probes Suitable for Cell‐and Tissue‐Based Protein Profiling and Single‐Cell Imaging Y Chang, D Zhu, H Guo, X Yin, K Ding, Z Li ChemBioChem 20 (14), 1783-1788, 2019 | 8 | 2019 |
Four new norlignan glycoside isomers from the twigs of Cephalotaxus oliveri Mast. FC Meng, H Liu, XJ Huang, Y Chang, D Ren, LG Lin, QQ Zeng, ... Tetrahedron: Asymmetry 28 (12), 1686-1689, 2017 | 7 | 2017 |
Leucine-zipper and sterile-α motif kinase (ZAK): a potential target for drug discovery Y Chang, Q Zhang, Z Li, K Ding, X Lu Current Medicinal Chemistry 23 (33), 3801-3812, 2016 | 6 | 2016 |
Discovery of JND003 as a new selective estrogen-related receptor α agonist alleviating nonalcoholic fatty liver disease and insulin resistance L Mao, L Peng, X Ren, Y Chu, T Nie, W Lin, A Libby, Y Xu, Y Chang, C Lei, ... ACS bio & med chem Au 2 (3), 282-296, 2022 | 5 | 2022 |
Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia Y Yang, Q Yu, L Hu, B Dai, R Qi, Y Chang, Q Zhang, Z Zhang, Y Li, ... European Journal of Medicinal Chemistry 244, 114731, 2022 | 4 | 2022 |
New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity B Tang, Z Li, L Li, B Li, Y Bian, G Yu, Y Chang, SM Lee, X Zhang Fitoterapia 156, 105085, 2022 | 4 | 2022 |
Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy Y Bao, Y Qiao, JE Choi, Y Zhang, R Mannan, C Cheng, T He, Y Zheng, ... Proceedings of the National Academy of Sciences 120 (49), e2314416120, 2023 | 3 | 2023 |
Proteome-wide Identification of Off-Targets of a Potent EGFRL858R/T790M Mutant Inhibitor P Lyu, K Jiang, Y Zhou, J Hu, Y Chang, Z Zhang, M Huang, ZM Zhang, ... ACS Medicinal Chemistry Letters 13 (2), 292-297, 2022 | 2 | 2022 |
Studies of pharmacokinetics in beagle dogs and drug-drug interaction potential of a novel selective ZAK inhibitor 3h for hypertrophic cardiomyopathy treatment W Jiang, L Ding, T Dai, J Guo, R Dai, Y Chang Journal of Pharmaceutical and Biomedical Analysis 172, 206-213, 2019 | 2 | 2019 |