| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 616 | 2020 |
| An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 373 | 2020 |
| Smoothened stimulation by membrane sterols drives Hedgehog pathway activity I Deshpande, J Liang, D Hedeen, KJ Roberts, Y Zhang, B Ha, ... Nature 571 (7764), 284-288, 2019 | 181 | 2019 |
| Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 128 | 2021 |
| RPA mediates recruitment of MRX to forks and double-strand breaks to hold sister chromatids together A Seeber, AM Hegnauer, N Hustedt, I Deshpande, J Poli, J Eglinger, ... Molecular cell 64 (5), 951-966, 2016 | 72 | 2016 |
| Structural basis of Mec1-Ddc2-RPA assembly and activation on single-stranded DNA at sites of damage I Deshpande, A Seeber, K Shimada, JJ Keusch, H Gut, SM Gasser Molecular cell 68 (2), 431-445. e5, 2017 | 71 | 2017 |
| Smoothened transduces hedgehog signals via activity-dependent sequestration of PKA catalytic subunits CD Arveseth, JT Happ, DS Hedeen, JF Zhu, JL Capener, D Klatt Shaw, ... PLoS biology 19 (4), e3001191, 2021 | 47 | 2021 |
| Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury N Kayagaki, IB Stowe, K Alegre, I Deshpande, S Wu, Z Lin, OS Kornfeld, ... Nature, 1-3, 2023 | 46 | 2023 |
| EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer A Mal, AB Bukhari, RK Singh, A Kapoor, A Barai, I Deshpande, ... Frontiers in cell and developmental biology, 1637, 2021 | 18 | 2021 |
| The Sir4 HBRCT domain interacts with phosphoproteins to sequester and repress yeast heterochromatin I Deshpande, JJ Keusch, K Challa, V Iesmantavicius, SM Gasser, H Gut The EMBO journal 38 (20), e101744, 2019 | 8 | 2019 |
| GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway N Hoppe, S Harrison, SH Hwang, Z Chen, M Karelina, I Deshpande, ... Nature Structural & Molecular Biology, 1-11, 2024 | 3 | 2024 |
| Docking for EP4R antagonists active against inflammatory pain S Gahbauer, C DeLeon, JM Braz, V Craik, HJ Kang, X Wan, XP Huang, ... Nature Communications 14 (1), 8067, 2023 | 1 | 2023 |
| Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody I Deshpande, A Manglik Hedgehog Signaling: Methods and Protocols, 149-160, 2022 | | 2022 |
| Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor (preprint) P Roboti, KB Duah, G Zong, H Schneider, WQ Shi, S High, ID Young, ... | | 2020 |
| Refining nanobody affinity with algorithmically-guided directed evolution AJ Riesselman, I Deshpande, J Liang, AC Kruse, A Manglik, DS Marks Building maps from genetic sequences to biological function, 68, 2019 | | 2019 |
| Assembly and activation of DNA damage sensing kinase Mec1-Ddc2 I Deshpande University_of_Basel, 2017 | | 2017 |
