(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism Y Ago, W Tanabe, M Higuchi, S Tsukada, T Tanaka, T Yamaguchi, ... International Journal of Neuropsychopharmacology 22 (10), 665-674, 2019 | 73 | 2019 |
(S)-norketamine and (2S, 6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression R Yokoyama, M Higuchi, W Tanabe, S Tsukada, M Naito, T Yamaguchi, ... Pharmacology Biochemistry and Behavior 191, 172876, 2020 | 53 | 2020 |
Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses M Niu, A Kasai, M Tanuma, K Seiriki, H Igarashi, T Kuwaki, K Nagayasu, ... Science advances 8 (11), eabi6375, 2022 | 34 | 2022 |
Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites Y Ago, R Yokoyama, S Asano, H Hashimoto Neuropharmacology 223, 109313, 2023 | 10 | 2023 |
Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells A Kohyama, R Yokoyama, DF Dibwe, S El-Mekkawy, MR Meselhy, ... Bioorganic & Medicinal Chemistry Letters 30 (7), 126964, 2020 | 10 | 2020 |
Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate A Kohyama, MJ Kim, R Yokoyama, S Sun, AM Omar, ND Phan, ... Bioorganic & Medicinal Chemistry 54, 116563, 2022 | 6 | 2022 |
(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice R Yokoyama, Y Ago, H Igarashi, M Higuchi, M Tanuma, Y Shimazaki, ... Molecular Psychiatry, 1-11, 2024 | 1 | 2024 |
Altered functional connectivity of the orbital cortex and striatum associated with catalepsy induced by Dopamine D1 and D2 antagonists M Niu, A Kasai, K Seiriki, M Hayashida, M Tanuma, R Yokoyama, Y Hirato, ... Biological and Pharmaceutical Bulletin 44 (3), 442-447, 2021 | 1 | 2021 |
Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice R Yokoyama, M Higuchi, W Tanabe, S Tsukada, H Igarashi, K Seiriki, ... Journal of Pharmacological Sciences 154 (2), 72-76, 2024 | | 2024 |
Activation of the Rostral Agranular Insular Cortex is Involved in the Antidepressant Actions of Arketamine Y Ago, R Yokoyama, A Kasai, M Tanuma, M Hayashida, Y Shimazaki, ... NEUROPSYCHOPHARMACOLOGY 47 (SUPPL 1), 267-268, 2022 | | 2022 |