CRAF methylation by PRMT6 regulates aerobic glycolysis–driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation TL Wong, KY Ng, KV Tan, LH Chan, L Zhou, N Che, RLC Hoo, TK Lee, ... Hepatology 71 (4), 1279-1296, 2020 | 87 | 2020 |
PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation LH Chan, L Zhou, KY Ng, TL Wong, TK Lee, R Sharma, JH Loong, ... Cell reports 25 (3), 690-701. e8, 2018 | 81 | 2018 |
Reprogramming of central carbon metabolism in cancer stem cells TL Wong, N Che, S Ma Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (7 …, 2017 | 79 | 2017 |
FSTL1 promotes metastasis and Chemoresistance in esophageal squamous cell carcinoma through NFκB–BMP signaling cross-talk MCC Lau, KY Ng, TL Wong, M Tong, TK Lee, XY Ming, S Law, NP Lee, ... Cancer research 77 (21), 5886-5899, 2017 | 67 | 2017 |
FSTL1 secreted by activated fibroblasts promotes hepatocellular carcinoma metastasis and stemness JJ Loh, TW Li, L Zhou, TL Wong, X Liu, VWS Ma, CM Lo, K Man, TK Lee, ... Cancer research 81 (22), 5692-5705, 2021 | 53 | 2021 |
Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma JHC Loong, TL Wong, M Tong, R Sharma, L Zhou, KY Ng, HJ Yu, CH Li, ... The Journal of clinical investigation 131 (11), 2021 | 51 | 2021 |
Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression L Zhou, HO Ken, TL Wong, Z Zhang, CH Chan, JHC Loong, N Che, HJ Yu, ... Gut 71 (8), 1656-1668, 2022 | 38 | 2022 |
Caspase-3–Induced activation of SREBP2 drives drug resistance via promotion of cholesterol biosynthesis in hepatocellular carcinoma EHK Mok, CON Leung, L Zhou, MML Lei, HW Leung, M Tong, TL Wong, ... Cancer Research 82 (17), 3102-3115, 2022 | 32 | 2022 |
Chemotherapy‐enriched THBS2‐deficient cancer stem cells drive hepatocarcinogenesis through matrix softness induced histone H3 modifications KY Ng, QT Shea, TL Wong, ST Luk, M Tong, CM Lo, K Man, JP Yun, ... Advanced Science 8 (5), 2002483, 2021 | 30 | 2021 |
The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression NPY Ho, CON Leung, TL Wong, EYT Lau, MML Lei, EHK Mok, HW Leung, ... Cell Death & Disease 12 (2), 148, 2021 | 28 | 2021 |
PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors Q Yan, Y Zhang, X Fang, B Liu, TL Wong, L Gong, S Liu, D Yu, M Liu, ... Cell Death & Differentiation 28 (6), 1955-1970, 2021 | 21 | 2021 |
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability N Che, KY Ng, TL Wong, M Tong, PWF Kau, LH Chan, TK Lee, MSY Huen, ... Cancer Letters 501, 247-262, 2021 | 21 | 2021 |
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer M Tong, TL Wong, H Zhao, Y Zheng, YN Xie, CH Li, L Zhou, N Che, ... Cell reports 36 (8), 2021 | 18 | 2021 |
A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment F Xu, M Tong, CSW Tong, BKC Chan, HY Chu, TL Wong, JHC Fong, ... Cancer Research 81 (24), 6219-6232, 2021 | 17 | 2021 |
Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen‐Activated Protein Kinase Kinase 6–Dependent p38 Mitogen‐Activated Protein Kinase Signaling to … ST Luk, KY Ng, L Zhou, M Tong, TL Wong, H Yu, CM Lo, K Man, XY Guan, ... Hepatology 72 (1), 183-197, 2020 | 17 | 2020 |
SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling H Yu, L Zhou, JHC Loong, KH Lam, TL Wong, KY Ng, M Tong, VWS Ma, ... Hepatology 78 (6), 1711-1726, 2023 | 11 | 2023 |
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer TL Wong, JJ Loh, S Lu, HHN Yan, HC Siu, R Xi, D Chan, MJF Kam, ... Nature communications 14 (1), 2861, 2023 | 9 | 2023 |
Protein tyrosine kinase 7 (PTK7) promotes metastasis in hepatocellular carcinoma via SOX9 regulation and TGF-β Signaling TLM Wong, TL Wong, L Zhou, K Man, J Purcell, TK Lee, JP Yun, S Ma Cellular and Molecular Gastroenterology and Hepatology 15 (1), 13-37, 2023 | 8 | 2023 |
Long noncoding RNA URB1-antisense RNA 1 (AS1) suppresses sorafenib-induced ferroptosis in hepatocellular carcinoma by driving ferritin phase separation Y Gao, M Tong, TL Wong, KY Ng, YN Xie, Z Wang, H Yu, JJ Loh, M Li, ... ACS nano 17 (22), 22240-22258, 2023 | 5 | 2023 |
Deranged tyrosine metabolism drives tumorigenesis in liver cancer M Tong, TL Wong, STC Luk, N Che, XY Guan, YF Yuan, TKW Lee, S Ma Cancer Research 78 (13_Supplement), 1432-1432, 2018 | 1 | 2018 |